One big name is already out and others could follow in the final round of matches.
In the Europa League, West Ham, Leicester, Celtic and Rangers have had mixed campaigns, while Tottenham's chances of progressing in the Europa Conference League are hanging in the balance.
Here is the state of play.
Champions League
Who is through to the knockout stage?
Group winners: Manchester City, Liverpool, Ajax, Bayern Munich, Manchester United.
Already qualified: Juventus, Chelsea, Paris St-Germain, Sporting Lisbon, Real Madrid, Inter Milan.
Out: Besiktas, RB Leipzig, Malmo, Dynamo Kyiv, Young Boys, Zenit St Petersburg, Club Bruges, Borussia Dortmund, Sheriff Tiraspol, Shakhtar Donetsk
Who else can still reach the knockout stage?
Group B: Porto, Atletico Madrid, AC Milan
Group E: Barcelona, Benfica
Group F: Villarreal, Atalanta
Group G: Red Bull Salzburg, Lille, Wolfsburg, Sevilla
What do sides need to do to qualify?
Manchester City seal top spot
Group A
Finals games: RB Leipzig v Manchester City, Paris St-Germain v Club Bruges on 7 December (17:45 GMT)
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